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UMN Medical School research uncovers how to treat diastolic heart failure



Research shows that magnesium improves a form of heart failure previously without treatment

Research from the University Minnesota Medical School and published in the Journal of Clinical Investigation Insight reveals what causes the diastolic heart failure and how it can

In the article, "the addition of magnesium improves mitochondrial and diastolic cardiac diabetic function", author Samuel Dudley, MD, PhD, chief academic of cardiology at the University of Minnesota Medical School and its fellow researchers have found that magnesium can be used to treat diastolic heart failure.

"We found that mitochondrial cardiac oxidative stress can cause diastolic dysfunction. Because magnesium is an essential element for mitochondrial function, we decided to try the supplement as a treatment," explained Dudley. "It has eliminated poor cardiac relaxation that causes diastolic heart failure."

Obesity and diabetes are known risk factors for cardiovascular disease. The researchers found that magnesium supplement also improves mitochondrial function and blood sugar in subjects.

Patients with diastolic heart failure have a high morbidity, mortality and health costs. Patients with this condition have an annual mortality similar to that of patients with systolic heart failure, and until now no specific treatments for this type of heart failure have been known.

"This is an exciting step forward in the cardiovascular field," Dudley said. "There are currently no specific treatments for patients with diastolic heart failure, but we now have a theory of why diastolic heart failure occurs. and what we can do to get rid of it. "

The next step is human trials. Dudley says this work could also open doors for responses to a related condition, atrial fibrillation.

Source:

https://www.med.umn.edu/news-events/umn-medical-school-researchers- discover-how-treat-diastolic-heart-failure

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